All I can think of are ridiculous weapons like Nicolas D Wolfwood's huge cross weapon from
Trigun.

It's an odd choice of weapon since it seems to be too cumbersome to be practical.
[Edit]
I now recall a couple more after some thought:
(2) The boxing gloves used by the titular character of Ryoko Okami from
Ōkami-san to Shichinin no Nakama-tachi (
Okami-san and Her Seven Companions) are these ridiculously cute kitty designs, but she's lethal with them just the same.
(3) Finally, the series
Mahoromatic is full of ridiculous, over-the-top action, and the "breast missiles" do not disappoint:
[Edit 2] (She's not the titular character for nothing!)